Inodilator (positive inotrope + vasodilator)
Vetmedin (Pimobendan)
The most commonly prescribed medication for dogs with DCM. Vetmedin strengthens the heart's contractions while reducing the workload on the heart.
Quick facts
Drug class
Inodilator (positive inotrope + vasodilator)
Estimated cost
$30–80/month depending on dog size and pharmacy. Generic pimobendan is often significantly cheaper than brand-name Vetmedin.
Also known as
Vetmedin (Pimobendan)
How it works
Pimobendan works in two ways: it increases the sensitivity of the heart muscle to calcium, which strengthens contractions (positive inotropy), and it relaxes blood vessels, reducing the resistance the heart has to pump against (vasodilation). This dual action makes the heart pump more effectively while requiring less effort.
Common dosage
Typically 0.25–0.3 mg/kg twice daily, given on an empty stomach (at least 1 hour before food). Your veterinarian will determine the exact dose based on your dog's weight and condition. The medication comes in chewable tablets.
Dosages vary — your vet will determine the right dose for your dog.
Side effects to watch for
- ●Loss of appetite (usually temporary)
- ●Lethargy or restlessness
- ●Diarrhea
- ●Increased heart rate
- ●Difficulty breathing (seek immediate vet attention)
- ●Rarely: fluid retention
Drug interactions
- ●Beta-blockers (like atenolol) — may reduce effectiveness
- ●Calcium channel blockers (like diltiazem) — combined use requires careful monitoring
- ●Other positive inotropes — increased risk of arrhythmias
Frequently asked questions
Other DCM medications
Important:Never start, stop, or adjust your dog's medication without consulting your veterinarian. The dosages and protocols described here are general references — your vet will determine the right approach for your dog based on their individual condition, weight, and overall health.