ACE inhibitor (angiotensin-converting enzyme inhibitor)
Enacard (Enalapril)
An ACE inhibitor used to reduce cardiac workload and manage heart failure symptoms in dogs with DCM. Enalapril works similarly to benazepril but is typically given twice daily for more consistent blood levels throughout the day.
Quick facts
Drug class
ACE inhibitor (angiotensin-converting enzyme inhibitor)
Estimated cost
$10–30/month. One of the most affordable ACE inhibitors. Widely available as a generic.
Also known as
Enacard, Vasotec (Enalapril)
How it works
Enalapril is a prodrug — it is converted by the liver into its active form, enalaprilat. This active form blocks the angiotensin-converting enzyme, preventing the production of angiotensin II. The result is relaxed blood vessels, lower blood pressure, and reduced fluid retention, all of which ease the burden on a failing heart. Unlike benazepril, enalapril relies primarily on renal (kidney) excretion, which means kidney function should be monitored more closely.
Common dosage
Typically 0.25–0.5 mg/kg twice daily. The twice-daily dosing is important because enalapril has a shorter duration of action than benazepril. It can be given with or without food, though giving it consistently at the same times each day helps maintain steady blood levels.
Dosages vary — your vet will determine the right dose for your dog.
Side effects to watch for
- ●Low blood pressure (hypotension) — watch for weakness or wobbliness
- ●Reduced appetite
- ●Elevated kidney values (BUN, creatinine)
- ●GI upset (vomiting, diarrhea) — more common than with benazepril
- ●Lethargy
- ●Rarely: elevated potassium levels (hyperkalemia)
Drug interactions
- ●NSAIDs (anti-inflammatory pain medications) — can reduce effectiveness and increase kidney risk
- ●Potassium supplements or potassium-sparing diuretics (like spironolactone) — increased risk of hyperkalemia
- ●Furosemide — commonly used together but requires regular kidney and electrolyte monitoring
- ●Other blood pressure-lowering medications — risk of additive hypotension
Frequently asked questions
Other DCM medications
Important:Never start, stop, or adjust your dog's medication without consulting your veterinarian. The dosages and protocols described here are general references — your vet will determine the right approach for your dog based on their individual condition, weight, and overall health.