Fortekor (Benazepril)

How it works

Benazepril blocks the angiotensin-converting enzyme (ACE), which prevents the formation of angiotensin II — a potent vasoconstrictor. This relaxes blood vessels, lowers blood pressure, and reduces the resistance the heart must pump against (afterload). It also decreases aldosterone secretion, which helps reduce fluid retention. Benazepril is unique among ACE inhibitors because it is excreted through both the liver and kidneys (dual excretion pathway), making it a preferred choice for dogs with compromised kidney function.

Common dosage

Typically 0.25–0.5 mg/kg once daily. Some cardiologists may prescribe twice daily dosing depending on the severity of disease. Benazepril can be given with or without food, which makes it convenient for many owners.

Dosages vary — your vet will determine the right dose for your dog.

Side effects to watch for

• ●Low blood pressure (hypotension) — watch for weakness, wobbliness, or collapse
• ●Reduced appetite
• ●Elevated kidney values (BUN, creatinine) — usually mild and manageable
• ●Lethargy
• ●Rarely: vomiting or diarrhea
• ●Rarely: elevated potassium levels (hyperkalemia)

Drug interactions

• ●NSAIDs (anti-inflammatory pain medications) — can reduce the effectiveness of benazepril and increase risk of kidney damage
• ●Potassium supplements or potassium-sparing diuretics (like spironolactone) — increased risk of dangerously high potassium levels (hyperkalemia)
• ●Furosemide — commonly used together, but the combination requires regular kidney value and electrolyte monitoring
• ●Other blood pressure-lowering medications — additive effects may cause excessive blood pressure drops

Frequently asked questions